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Effect of Rimonabant on Body Weight and the Metabolic Syndrome in Overweight Patients. A CB1 antagonist called rimonabant is currently marketed overseas for weight loss. Rimonabant is not yet approved for use in the United States, where it is known as Zimulti. 16 issue of the British Medical Journal, Padwal's team found that long-term users of weight-loss drugs such as orlistat (Xenical), sibutramine (Meridia) and rimonabant experienced only modest weight loss -- less than 11 pounds, which was less than 5 percent of their total body weight. "If one is using rimonabant, patients should be monitored carefully for the emergence of depressive symptoms and/or suicidal thoughts," he added.

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